Excitatory neuron-specific somatic mutation count

Age is associated with excitatory neuron-specific somatic mutation count in humans.

“The count of ENSMs per individual also showed an increasing trend with age.”

Humansexcitatory neuronn = 76

Identifying aging and Alzheimer’s disease associated somatic mutations in excitatory neurons from the human frontal cortex using whole genome sequencing and single cell RNA sequencing data

medRxiv·May 26, 2022Preprint