RANKL and OPG expression

Older donor age is associated with RANKL and OPG expression in mouse cells (RANKL increased; OPG decreased).

“the expression of RANKL was dramatically increased, and OPG was decreased in aged MSCs.”

Cellsbone marrow mesenchymal stem cell

Decreased osteogenesis in mesenchymal stem cells derived from the aged mouse is associated with enhanced NF-κB activity

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·Apr 23, 2016