PTGS2, DRD4, SST, and CREB1 expression

Human aging is associated with PTGS2, DRD4, SST, and CREB1 expression in humans.

“the PFC exhibits marked reductions in the expression of genes critical for synaptic integrity and layer II/III glutamatergic signaling, such as PTGS2, DRD4, SST, and CREB1.”

Reviewhuman agingprefrontal cortex

Transcriptomic Divergence Between Prefrontal Cortex and Limbic Circuits in Human Aging

Preprints.org·20 Jan 2026Preprint