ProtAgeGap polygenic score

1. ProtAgeGap polygenic score is associated with developmental timing in humans.

   “ProtAgeGap PGS with obesity, cardiometabolic disease, and osteoarthritis in adults, and with developmental timing in children.”

   Humans

   Genome-wide association study of proteomic aging reveals shared genetic architectures with longevity, early life development, and age-related diseases

   medRxiv·4 Dec 2025Preprint

1. ProtAgeGap polygenic score is associated with obesity, cardiometabolic disease, and osteoarthritis in humans.

   “demonstrate reproducible associations across biobanks of ProtAgeGap PGS with obesity, cardiometabolic disease, and osteoarthritis in adults”

   HumansReproducible associations across biobanks

   Genome-wide association study of proteomic aging reveals shared genetic architectures with longevity, early life development, and age-related diseases

   medRxiv·4 Dec 2025Preprint

More on Obesity, cardiometabolic disease, and osteoarthritis

1. ProtAgeGap polygenic score is associated with achieving longevity in humans (OR = 1.43).

   “in FinnGen a ProtAgeGap polygenic score (PGS) was associated with significantly increased odds of achieving longevity (n=500,348; OR = 1.43).”

   HumansFinnGenn = 500,348

   Genome-wide association study of proteomic aging reveals shared genetic architectures with longevity, early life development, and age-related diseases

   medRxiv·4 Dec 2025Preprint