Premature epigenetic aging

8 papers mention it3 findings

1 new paper in 30 daysSee all 8 papers on premature epigenetic aging

“Premature epigenetic aging estimated using Horvath's clock was associated with more negative deviations from normative volume of the putamen and caudate”

Premature epigenetic aging, deviations from normative brain development, and cognitive performance in young adulthoodTranslational psychiatry2026doi:10.1038/s41398-026-04337-3

Associations

Cognitive function

mixedin humans1

1 study

Premature epigenetic aging is associated with cognitive function in humans (epigenetic aging estimated using Horvath's DNA methylation clock; U-shaped relationship).
“In men, the relationship between premature epigenetic aging and cognitive performance was quadratic (U-shaped).”
Humansepigenetic aging estimated using Horvath's DNA methylation clock; U-shaped relationshipmales
Aging measure linked to smaller brain regions in young adults
Translational psychiatryAug 6, 2026

Full-Scale IQ

downin humans1

1 study

Premature epigenetic aging is associated with full-Scale IQ in humans (epigenetic aging estimated using Horvath's DNA methylation clock).
“In women, this premature epigenetic aging was also associated with lower full-scale IQ and performance IQ”
Humansepigenetic aging estimated using Horvath's DNA methylation clockfemales
Aging measure linked to smaller brain regions in young adults
Translational psychiatryAug 6, 2026

Normative putamen and caudate volume deviations

downin humans1

1 study

Premature epigenetic aging is associated with normative putamen and caudate volume deviations in humans (epigenetic aging estimated using Horvath's DNA methylation clock).
“Premature epigenetic aging estimated using Horvath's clock was associated with more negative deviations from normative volume of the putamen and caudate”
Humansepigenetic aging estimated using Horvath's DNA methylation clockputamen and caudaten = 254
Aging measure linked to smaller brain regions in young adults
Translational psychiatryAug 6, 2026

Latest

3 papers in 12 months

Translational PsychiatryNov 4

Aging measure linked to smaller brain regions in young adults

An observational analysis of 254 adults aged 28–30 also linked the DNA-based measure to lower intelligence-test scores in women.An observational analysis of 254 adults aged 28–30 also linked the DNA-based measure to lower intelligence-test scores in women.

Cross-sectional · 254 peopleBiomarkers