Prelamin A accumulation

1. LMNA increases prelamin A accumulation in humans.

   “Here we show that this mutation causes accumulation of the lamin A precursor protein”

   HumansLMNA mutation causing mandibuloacral dysplasia type A

   Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy

   Physiological genomics·26 Jul 2005

More on LMNA