Predictive performance

Biomarker

1 paper2 findings

  • In silico1

Interventions

2

Random forest

downin humans1

1 study
  1. Random forest decreases predictive performance in humans.

    “random forest again performed worse”

    Humansrisk prediction of ischemic heart disease

    Genetic Architecture and Sample Size Impact Relative Performance of Nonlinear Machine Learning and Standard Polygenic Risk Scores

    medRxiv3 Sep 2026Preprint

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Xgboost

no changein humans1

1 study
  1. Xgboost has no effect on predictive performance in humans.

    “XGBoost showed little improvement in predictive performance over standard PRSs”

    Humansrisk prediction of ischemic heart disease

    Genetic Architecture and Sample Size Impact Relative Performance of Nonlinear Machine Learning and Standard Polygenic Risk Scores

    medRxiv3 Sep 2026Preprint

More on Xgboost

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BMC Geriatrics

Frailty and a metabolic measure linked to risk of death

An observational study of 2,573 UK and 803 Chinese older adults with atrial fibrillation and no diabetes linked combined metabolic and frailty assessments to differing…An observational study of 2,573 UK and 803 Chinese older adults with atrial fibrillation and no diabetes linked combined metabolic and frailty assessments to differing death risks.

Cohort study of 2,573 peopleBiomarkers
Cardiovascular Diabetology

Combined blood marker linked to cardiovascular disease risk

An observational study followed 5,474 Chinese participants from 2011 to 2020 and linked higher marker values to progression to clinical cardiovascular disease.An observational study followed 5,474 Chinese participants from 2011 to 2020 and linked higher marker values to progression to clinical cardiovascular disease.

Cohort study of 5,474 peopleCardiovascular disease
Eye and Vision

Combined blood fat and sugar measures linked to glaucoma

The basic blood fat–glucose measure had a hazard ratio—a comparison of glaucoma rates—of 1.05 in a cohort of 396,213 UK participants.The basic blood fat–glucose measure had a hazard ratio—a comparison of glaucoma rates—of 1.05 in a cohort of 396,213 UK participants.

Cohort study of 396,213 peopleGlaucoma
NPJ Digital Medicine

Health vulnerability score is linked to disease and death

In 35,193 healthy adults followed for over a decade, each one-unit score rise was linked to a hazard ratio of 2.60 for disease progression.In 35,193 healthy adults followed for over a decade, each one-unit score rise was linked to a hazard ratio of 2.60 for disease progression.

Cohort study of 391,193 peopleBiomarkers