Predicted expression changes relative to the endogenous aging transcriptional program

1. Somatic mutations are associated with predicted expression changes relative to the endogenous aging transcriptional program in silico (Three to four orders of magnitude below the endogenous aging transcriptional program).

   “produce predicted expression changes whose distributions lie three to four orders of magnitude below the tissue’s endogenous aging transcriptional program.”

   In silicoAlphaGenome predictions for random and real somatic variantscolonic epithelium

   Testing the mutation accumulation hypothesis in aging with AlphaGenome

   bioRxiv (Cold Spring Harbor Laboratory)·15 May 2026Preprint

More on Somatic mutations