Polygenic disease risk

Estrogen-responsive variants interact with reproductive risk factors

In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at first birth (p=0.0052).In 13,026 post-menopausal cases and 108,265 controls, an estrogen-responsive polygenic score interacted with reproductive traits including age at first birth (p=0.0052).