Plasma taurine/total amino acid ratio

Plasma taurine/total amino acid ratio is associated with PHAI-based unhealthy ageing in humans (HR 0.77, 95% CI 0.59–1.00).

“lower risk of PHAI-based unhealthy ageing (HR, 0.77; 95% CI, 0.59–1.00; P for trend = .04) versus the lowest quartile.”

HumansHighest versus lowest quartile; PHAI score ≤25th percentileplasma2001–202251.4% femalesn = 2,321

Plasma Taurine Relative Abundance, Not Dietary Intake or Genetic Predisposition, Predicts All-Cause Mortality and Unhealthy Ageing: A Prospective Cohort Study

medRxiv·13 Jul 2026Preprint

Plasma taurine/total amino acid ratio is associated with mortality in humans (29% lower mortality; HR 0.71, 95% CI 0.52–0.98).

“Participants in the highest quartile showed 29% lower all-cause mortality (Hazard Ratio [HR], 0.71; 95% Confidence Interval [CI], 0.52–0.98; P for trend = .04)”

HumansHighest versus lowest quartileplasma2001–202251.4% femalesn = 2,321

Plasma Taurine Relative Abundance, Not Dietary Intake or Genetic Predisposition, Predicts All-Cause Mortality and Unhealthy Ageing: A Prospective Cohort Study

medRxiv·13 Jul 2026Preprint