Plasma proteomic signatures
Biomarker1 paper1 finding
- Humans1
Associations
1Cardiovascular, kidney and mortality outcomes
upin humans1
1 study
Cardiovascular, kidney and mortality outcomes
upin humans1
Plasma proteomic signatures predict cardiovascular, kidney and mortality outcomes in humans (ΔC-index 0.024-0.070).
Humansearly CKM stages 0-2
Blood proteins improve early cardiometabolic risk prediction · Diabetes, obesity & metabolism · 30 Sep 2026
Latest
4An 11-protein blood score tracks incident dementia risk
In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard…In over 36,000 UK Biobank participants, the signature raised Harrell's C-index from 0.798 to 0.862, carrying a hazard ratio of 2.645 per standard deviation increase.
Proteomic organ clocks predict mortality but trail established physiological and epigenetic biomarkers
In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.In an older Scottish cohort, epigenetic age and brain volume outmatched plasma proteomic organ clocks for predicting long-term all-cause mortality.
Blood proteins improve early cardiometabolic risk prediction
In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes…In 43,709 adults with early-stage disease, outcome-specific proteomic signatures improved clinical risk discrimination across 11 incident outcomes, boosting C-index values by 0.024 to 0.070.