phyloAge

1. Acute myeloid leukemia increases phyloAge in humans (168 years more than chronological ages).

   “VFS-based HSC phyloAge estimates were, on average, 168 years more than chronological ages in 157 patients with acute myeloid leukemia”

   Humansacute myeloid leukemian = 157

   An Evolutionary Metric for Estimating PhyloAges from Bulk Sequencing of Hematopoietic Stem Cells Reveals the Tempo of Blood Aging in Cancer and Longevity

   Journal of molecular evolution·26 Dec 2025

More on Acute myeloid leukemia

1. Longevity is associated with phyloAge in humans.

   “HSC phyloAge estimates were significantly lower, consistent with reduced hematologic cancer risk among extremely old individuals.”

   Humanslong-lived individuals

   An Evolutionary Metric for Estimating PhyloAges from Bulk Sequencing of Hematopoietic Stem Cells Reveals the Tempo of Blood Aging in Cancer and Longevity

   Journal of molecular evolution·26 Dec 2025