Personalized-context-Aware Age Gap

1. Personalized-context-Aware Age Gap improves clinical outcome prediction in silico.

   “We demonstrate that PAAG, generated via fine-tuning AOE-Net, significantly outperforms AG of conventional first- and second-generation aging clocks in predicting clinical outcomes.”

   In silicoin predicting clinical outcomes

   Personalized-Context-Aware Age Gap: A New Multi-Omics Measurement Based on Age-Enhanced Model AOE-Net for Aging Acceleration and Chronic Disease Risk Prediction

   Aging cell·29 May 2026

1. Personalized-context-Aware Age Gap is associated with immune response in silico.

   “Furthermore, interpretive analysis of PAAG's molecular drivers revealed a strong functional enrichment for immune-response pathways, providing a shared mechanistic link between accelerated aging and disease.”

   In silicomolecular drivers of PAAG

   Personalized-Context-Aware Age Gap: A New Multi-Omics Measurement Based on Age-Enhanced Model AOE-Net for Aging Acceleration and Chronic Disease Risk Prediction

   Aging cell·29 May 2026

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