Advanced Science
Valve precursor cells promote age-related scarring in mice
Removing precursor cells reduced valve thickening and scarring in mice given daily D-galactose injections to model aging for about two months.Removing precursor cells reduced valve thickening and scarring in mice given daily D-galactose injections to model aging for about two months.
Mouse studyMechanisms
Who was studiedAging genetically modified mice of both sexes, against mice without cell depletion
What changedDepleting precursor-derived cells reduced aortic valve scarring compared with mice without cell depletion
The catchCell tracing does not exclude circulating progenitors as the source of scar-forming cells