PDE11A4 ghost axons

1 paper1 finding

Animals1

Interventions

1

Tadalafil

downin mice1−50%

1 study

Tadalafil decreases PDE11A4 ghost axons in mice (50%).
“Importantly, orally dosed tadalafil reduced PDE11A4 ghost axons in old mouse ventral hippocampus by 50%.”
Animalsin old miceoralventral hippocampus
Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors
Cells13 Jun 2025

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Cells25 Jun

Age-Related Increases in PDE11A4 Protein Expression Trigger Liquid-Liquid Phase Separation (LLPS) of the Enzyme That Can Be Reversed by PDE11A4 Small Molecule Inhibitors

Experiments in miceInterventions