Pathogenic autoimmune antibody secretion

1 paper2 findings

Humans1

Upstream

2

STAT3

mediatesin human cells1

1 study

STAT3 mediates pathogenic autoimmune antibody secretion in human cells.
“Mechanistically, the effects of lactate are mediated by phosphorylated signal transducer and activator of Transcription 3 (p-STAT3).”
CellsLactate stimulation; phosphorylated STAT3B cell
The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells
European journal of immunology1 Jan 2026

Lactate

upin human cells1

1 study

Lactate increases pathogenic autoimmune antibody secretion in human cells.
“we found increased secretion of pathogenic autoimmune antibodies in B cells from YLEAN, compared to those from YOBESE and ELEAN individuals”
CellsIn vitro stimulation; YLEAN compared with YOBESE and ELEAN donorsB cell
The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells
European journal of immunology1 Jan 2026

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European Journal of Immunology12 Jan

The Increased Secretion of Lactate Observed in Obesity and Aging Leads to the Generation of Pathogenic B Cells

Study in peopleBlood and immune system