p16Ink4a+ cancer-associated fibroblasts

1 paper1 finding

Animals1

Interventions

1

XL888

downin mice1

1 study

XL888 decreases p16Ink4a+ cancer-associated fibroblasts in mice.
“XL888, an HSP90 inhibitor, that clears p16Ink4a+ cancer-associated fibroblasts in vivo.”
Animalsadvanced LUAD
Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity
Cell stem cell3 Nov 2025

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Cell Stem Cell5 Nov

Senolytic-sensitive p16Ink4a+ fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity

Experiments in miceLung cancer