P16+ lymphocytes

1. Recurrent pregnancy loss is associated with p16+ lymphocytes in humans (0.06% vs 0.17% vs 0.35%, p < 0.01).

   “Corresponding increases were also detected for p16+ lymphocytes (0.06%, 0.17%, 0.35%; p < 0.01), p21+ granulocytes (0.78%, 5.75%, 11.7%; p = 0.04), and p53+ granulocytes (4.01%, 7.05%, 8.35%; p = 0.05).”

   Humansin early pregnancyperipheral bloodfemalesn = 52

   Disrupted immune senescence in early pregnancy is associated with recurrent pregnancy loss

   Frontiers in immunology·4 Feb 2026

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