Oxytocin

1. Estradiol suppression has no effect on oxytocin in humans (p≥0.15).

   “Following estradiol suppression, oxytocin levels and mood disturbance did not change significantly (p≥0.15).”

   Human trialserumfemalesn = 27

   SAT-127 Impact of Sleep Interruption on Circulating Oxytocin Levels and Mood Disturbance in Women Under High and Low Estradiol Conditions

   ENDO 2025 abstract·22 Oct 2025

More on Estradiol suppression

1. Sleep interruption increases oxytocin in humans (28.7±2.1 pg/mL vs. 36.4±2.2 pg/mL, p=0.002).

   “Oxytocin levels and mood disturbance significantly increased after sleep interruption across estradiol states ([mean±SE] 28.7±2.1 pg/mL vs. 36.4±2.2 pg/mL, p=0.002; 5.5±2.4 vs. 12.3±2.4, p<0.0001- respectively).”

   Human trialacross estradiol statesserum3 nightsfemalesn = 38

   SAT-127 Impact of Sleep Interruption on Circulating Oxytocin Levels and Mood Disturbance in Women Under High and Low Estradiol Conditions

   ENDO 2025 abstract·22 Oct 2025

More on Sleep interruption

1. Oxytocin is associated with cognitive decline in humans.

   “Lower ratios of CSF Aβ42/Aβ40 and LXA4/cys‐LT, along with higher CSF oxytocin levels, are associated with CD”

   Humansin older adultscerebrospinal fluid

   Cerebrospinal Fluid Biomarkers Profiling in Older Brazilians reveals that CSF leptin is associated with obesity but not with cognitive decline

   AAIC 2025 abstract·25 Dec 2025

1. Oxytocin is associated with mood disturbance in humans (Cohen’s d=0.49, p=0.024).

   “Higher oxytocin levels correlated with more mood disturbance (Cohen’s d=0.49, p=0.024).”

   Human trialfemales

   SAT-127 Impact of Sleep Interruption on Circulating Oxytocin Levels and Mood Disturbance in Women Under High and Low Estradiol Conditions

   ENDO 2025 abstract·22 Oct 2025