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Sleep interruption

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Human trial1

Outcomes

2

Mood disturbance

upin humans1

1 study

  1. Sleep interruption increases mood disturbance in humans (5.5±2.4 vs. 12.3±2.4, p<0.0001).

    “Oxytocin levels and mood disturbance significantly increased after sleep interruption across estradiol states ([mean±SE] 28.7±2.1 pg/mL vs. 36.4±2.2 pg/mL, p=0.002; 5.5±2.4 vs. 12.3±2.4, p<0.0001- respectively).”

    Human trialacross estradiol states3 nightsfemalesn = 38

    SAT-127 Impact of Sleep Interruption on Circulating Oxytocin Levels and Mood Disturbance in Women Under High and Low Estradiol Conditions

    ENDO 2025 abstract22 Oct 2025

Oxytocin

upin humans1

1 study

  1. Sleep interruption increases oxytocin in humans (28.7±2.1 pg/mL vs. 36.4±2.2 pg/mL, p=0.002).

    “Oxytocin levels and mood disturbance significantly increased after sleep interruption across estradiol states ([mean±SE] 28.7±2.1 pg/mL vs. 36.4±2.2 pg/mL, p=0.002; 5.5±2.4 vs. 12.3±2.4, p<0.0001- respectively).”

    Human trialacross estradiol statesserum3 nightsfemalesn = 38

    SAT-127 Impact of Sleep Interruption on Circulating Oxytocin Levels and Mood Disturbance in Women Under High and Low Estradiol Conditions

    ENDO 2025 abstract22 Oct 2025

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