Oligomeric amyloid-beta
Biomarker1 paper2 findings
- Human trial1
Interventions
2Cocoa extract
no changein humans1High certainty
1 study
Cocoa extract
no changein humans1High certainty
Cocoa extract has no effect on oligomeric amyloid-beta in humans (-5.9%; 95% CI: -21.4% to 12.6%; p = 0.51).
Human trial2 years
Effect of a multivitamin and cocoa flavanol extract on changes in neurofilament light, N-terminal tau fragment, and oligomeric amyloid-β levels in COSMOS-clinic · Journal of Alzheimer's disease : JAD · 23 Sep 2026
Multivitamin-multimineral
no changein humans1High certainty
1 study
Multivitamin-multimineral
no changein humans1High certainty
Multivitamin-multimineral has no effect on oligomeric amyloid-beta in humans (-8.9%; 95% CI: -23.9% to 9%; p = 0.31).
Human trial2 years
Effect of a multivitamin and cocoa flavanol extract on changes in neurofilament light, N-terminal tau fragment, and oligomeric amyloid-β levels in COSMOS-clinic · Journal of Alzheimer's disease : JAD · 23 Sep 2026