Number of impaired intrinsic capacity domains

Number of impaired intrinsic capacity domains are associated with mortality in humans (One domain: HR 1.48 (95% CI 1.26–1.75); two: 2.10 (1.67–2.65); three: 1.71 (1.14–2.57); four: 3.15 (1.53–6.46)).

“The risk of mortality increased progressively with the number of impaired intrinsic capacity domains:”

HumansCommunity-dwelling older adults in Indian = 4,096

Intrinsic capacity and survival among older adults in India: LASI-DAD study (wave 1 and wave 2)

The Lancet regional health. Southeast Asia·9 May 2026