Nature Communications
Fungal enzyme structure offers clues to RNA modification
Experiments with purified fungal protein revealed a heart-shaped pair and suggested that RNA positioning, rather than binding strength, drives its chemical modification.Experiments with purified fungal protein revealed a heart-shaped pair and suggested that RNA positioning, rather than binding strength, drives its chemical modification.
Experiments in cellsMechanisms
Who was studiedPurified fungal proteins
What changedtRNA acetylation was enabled by two conserved active site residues and two basic patches
The catchThe structural work examined synthetic probes, not an enzyme bound to RNA