Myelin sphingolipid and cholesterol replacement rates

Age is associated with myelin sphingolipid and cholesterol replacement rates in mice.

“Myelin sphingolipid and cholesterol replacement rates in the corpus callosum decreased markedly between 3 and 12 months of age”

Animalscorpus callosum

In vivo deuteration reveals pronounced variation in myelin lipid turnover rates and reduced myelin renewal with ageing

bioRxiv (Cold Spring Harbor Laboratory)·18 Feb 2026Preprint