Myelin lipid half-life

lipid class is associated with myelin lipid half-life in mice (Common glycerophospholipids: <2 months; many sphingolipids: >8 months).

“Half-lives of common glycerophospholipids in purified myelin were under 2 months whereas many sphingolipids exhibited half-lives exceeding 8 months”

Animalspurified myelin

In vivo deuteration reveals pronounced variation in myelin lipid turnover rates and reduced myelin renewal with ageing

bioRxiv (Cold Spring Harbor Laboratory)·18 Feb 2026Preprint