Myelin debris signature

1. Caloric restriction decreases myelin debris signature in rhesus monkeys.

   “Microglia from CR subjects upregulated amino acid and peptide metabolism pathways and showed a reduced myelin debris signature.”

   Animalslifelong, 30% calorie restrictionbrain white matter

   Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

   Aging cell·24 Nov 2025

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