bioRxiv
Cell cleanup limits faulty mitochondrial DNA inheritance in worms
In worm experiments, reproductive cells selectively removed mitochondria rich in faulty DNA before fertilization, limiting its transmission across generations.In worm experiments, reproductive cells selectively removed mitochondria rich in faulty DNA before fertilization, limiting its transmission across generations.
Preprint: worm studyMitochondrion
Who was studiedCaenorhabditis elegans worms
What changedBoosting cleanup in worm reproductive cells reduced inherited faulty mitochondrial DNA, ultimately eliminating it from the maternal line
The catchThe reduction in mutant DNA inheritance is reported without a numerical effect size