Multinucleated giant cell accumulation

1. INS2 increases multinucleated giant cell accumulation in mice.

   “Ins1 -/- ;Ins2 +/+ ovaries showed multinucleated giant cell accumulation with HFHS, while Ins1 -/- ;Ins2 +/- mice were protected against this response”

   AnimalsShown by partial versus full Ins2 expression in HFHS-fed Ins1-null miceovaryfemales

   Lowering insulin mitigates female reproductive aging and diet-induced ovarian dysfunction

   bioRxiv (Cold Spring Harbor Laboratory)·25 Dec 2025Preprint

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