Multinucleated giant cell abundance

Reproductive aging is associated with multinucleated giant cell abundance in dogs.

“In the bitch, reproductive aging associates with a decrease in follicle pool, an increase in multinucleated giant cells, and an increase in IgG accumulation.”

Animalsovaryfemales

Ovarian ROS-dependent IgG accumulation precedes lipofuscin deposition and follicular decline: comparative insights from the bitch and mouse models of ovarian aging

Frontiers in aging·30 May 2025