Mosaic burden threshold for excess mortality risk

phase-based quantification decreases mosaic burden threshold for excess mortality risk in humans.

“identified excess mortality risk at lower mosaic burdens than intensity-based metrics.”

Humansphase-based versus intensity-based quantificationmalesn = 223,251

Measurement strategy alters inferred age-dependent accumulation and mortality risk of mosaic Y loss

medRxiv·10 Mar 2026Preprint