Inferred age-dependent accumulation of mosaic loss of Y chromosome

phase-based quantification increases inferred age-dependent accumulation of mosaic loss of Y chromosome in humans.

“Phase-based quantification revealed a steeper and more stable age-dependent accumulation of mLOY”

Humansphase-based versus intensity-based quantificationmalesn = 223,251

Measurement strategy alters inferred age-dependent accumulation and mortality risk of mosaic Y loss

medRxiv·10 Mar 2026Preprint