Mitochondrial respiration rate

1. Older-adults decrease mitochondrial respiration rate in humans (PCr1: 12.03 ± 2.98 vs. 14.05 ± 2.11 pmol·s−1·106 cells−1; PGMS: 16.58 ± 3.56 vs. 20.61 ± 2.11 pmol·s−1·106 cells−1).

   “JO2 was similar between groups at baseline (P = 0.08) and lower energetic states (PCr2, PCr3; P ≥ 0.09), but was lower in older adults at higher energetic states”

   Humanshigher energetic states (PCr1 and PGMS)pbmc

   Peripheral blood mononuclear cell mitochondrial bioenergetics are related to vascular endothelial function in young and older adults

   American journal of physiology. Regulatory, integrative and comparative physiology·27 Jan 2026

1. SESN2 increases mitochondrial respiration rate in mice.

   “Seahorse analysis demonstrated that Sesn2 deficiency in aged and young Sesn2 KO versus young hearts lead to impaired mitochondrial respiration rate with defects in Complex I and Complex II activity.”

   Animalsshown by knockout; in young and aged heartsheart

   Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion

   Redox biology·1 Dec 2020

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