mtDNA large indels

1. POLG increases mtDNA large indels in mice.

   “Exo- tissues, especially post-mitotic tissues, evidenced exceptionally high burdens of mtDNA large indels (mtDNALIs).”

   Animalsin PolgD257A/D257A (exo-) micepost-mitotic tissues

   Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice

   Nucleic acids research·Jun 22, 2026

More on POLG

1. mtDNA large indels are associated with premature aging in mice.

   “accumulation of mtDNALIs, compounded by insufficient mechanisms for eliminating closed circular aberrant mtDNA, as contributing to the premature aging phenotype.”

   Animalsin PolgD257A/D257A mice

   Persistence of large mtDNA rearrangements linked to premature aging in Pol γ exonuclease-deficient mice

   Nucleic acids research·Jun 22, 2026