Mitochondrial D-loop methylation

Alzheimer's disease progression is associated with mitochondrial D-loop methylation in humans.

“individuals converting to AD exhibited a marked decrease in its level”

Humansin participants followed longitudinally over eight yearsbloodeight yearsn = 75

Longitudinal Analysis of Mitochondrial D-Loop Methylation and Copy Number in Peripheral Blood: Epigenetic Signatures of Alzheimer's Disease Progression and Aging

International journal of molecular sciences·2 Feb 2026