Mic-ADPRS

1. Mic-ADPRS impairs cognitive function in humans (beta= -15.0 x, SE = 1.8 x, p = < 0.001).

   “Mic-ADPRS was also associated with faster PACC decline (beta= -15.0 x, SE = 1.8 x, p = < 0.001).”

   Humanscognitively unimpaired older adultsn = 1,179

   Microglia‐specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults

   AAIC 2025 abstract·10 Jan 2026

1. Mic-ADPRS increases pTau217 in humans (beta = 13.9 x, SE = 2.4 x, p = <0.001).

   “Mic-ADPRS was associated with a longitudinal increase in pTau217 (beta = 13.9 x, SE = 2.4 x, p = <0.001)”

   Humanscognitively unimpaired older adultsplasman = 1,179

   Microglia‐specific Alzheimer's disease polygenic risk score predicts longitudinal increase in plasma tau and faster cognitive decline in cognitively unimpaired older adults

   AAIC 2025 abstract·10 Jan 2026

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