1 paper3 findings
Partial reprogramming
downin silico1
Partial reprogramming decreases mesenchymal drift in silico.
“Yamanaka factor-induced partial reprogramming can markedly reduce MD before dedifferentiation and gain of pluripotency”
In silicobefore dedifferentiation and gain of pluripotency
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Cell14 Aug 2025
Survival
downin silico1
Mesenchymal drift is associated with survival in silico.
“Increased MD correlates with disease progression, reduced patient survival, and an elevated mortality risk”
In silicoacross multiple cell types in human tissues and diseases
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Cell14 Aug 2025
Mortality
upin silico1
Mesenchymal drift is associated with mortality in silico.
“Increased MD correlates with disease progression, reduced patient survival, and an elevated mortality risk”
In silicoacross multiple cell types in human tissues and diseases
Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming
Cell14 Aug 2025
Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.