Membrane hydrophobicity

1. CRYAA increases membrane hydrophobicity in cells.

   “both WT-αAc and N101D-αAc membrane binding decreases 60-yo and 20-yo MHLL membrane mobility while increasing hydrophobicity and order near the headgroup region.”

   CellsWild-type and N101D protein binding; near the membrane headgroup regionmodel human lens lipid membranes

   Age-Related Lens Membrane Composition and N101D Deamidation Modulate αA-Crystallin Membrane Interactions Relevant to Cataract

   Investigative ophthalmology & visual science·1 Oct 2026

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