Maximal bioenergetic capacity

Biomarker1 paper2 findings

  • Cells1

Interventions

1

Human serum

downin human cells1Very low certainty

1 study

  1. Human serum decreases maximal bioenergetic capacity in human cells (R=-0.28, P=0.01).

    “maximal bioenergetic capacity of both younger and older fibroblasts treated with serum for 24 hours negatively correlates with the chronological age of the serum donor (R=-0.28, P=0.01”

    Cellsdonor age-dependent correlation in younger donor fibroblastsdiluted serumfibroblast24 hoursn = 88

    SERUM FACTORS DRIVE DIFFERENCES IN MITOCHONDRIAL BIOENERGETICS ASSOCIATED WITH HUMAN AGING · GSA 2024 abstract · 31 Dec 2024

Human serum →

Associations

1

GrimAge

downin human cells1

1 study

  1. GrimAge is associated with maximal bioenergetic capacity in human cells (R=-0.36, P< 0.01).

    “the effects of serum on fibroblasts derived from younger and older individuals were most closely related to GrimAge (R=-0.36, P< 0.01”

    Cellsserum-induced effects on younger fibroblastsfibroblast24 hoursn = 88

    SERUM FACTORS DRIVE DIFFERENCES IN MITOCHONDRIAL BIOENERGETICS ASSOCIATED WITH HUMAN AGING · GSA 2024 abstract · 31 Dec 2024

GrimAge →

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