Macular pigment optical density
13 papers study it13 more mention it19 findings
- Human trial3
- Humans10
Interventions
7Centella asiatica
upin humans1
1 study
Centella asiatica
upin humans1
Centella asiatica increases macular pigment optical density in humans (0.04 ± 0.03 vs. −0.01 ± 0.02).
“From baseline to Day 180, the change in average MPOD remained significantly greater in the CA-HE50 group than in the placebo group (0.04 ± 0.03 vs. −0.01 ± 0.02; p < 0.0001).”
Human trialsix monthsn = 80
Nutrients
Centella asiatica increases macular pigment optical density in humans (p < 0.001).
“supplementation with CA-HE50 resulted in a statistically significant increase in MPOD compared to the placebo in the right eye, left eye, and the average of both eyes (all p < 0.001).”
Human trialbaseline MPOD between 0.2 and 0.4CA-HE50macula300 mg/day6 monthsn = 80
Nutrients
Smoking
downin humans1
1 study
Smoking
downin humans1
Smoking decreases macular pigment optical density in humans.
“Smoking, obesity, poor dietary lutein intake, light iris color, and hyperlipidemia were associated with low MPOD.”
Humans
European journal of ophthalmology
Lutein
upin humans1
1 study
Lutein
upin humans1
Lutein increases macular pigment optical density in humans (3.69 ± 1.82 to 5.02 ± 1.35 dB).
“Average MPOD values in the AMD group were; 3.69 ± 1.82 (baseline), 4.74 ± 1.29 (3rd month), 4.99 ± 1.27 (6th month), and 5.02 ± 1.35 (9th month) dB, respectively.”
Human trialin dry AMD patients9 months
European journal of ophthalmology
Mediterranean diet
upin humans1
1 study
Mediterranean diet
upin humans1
Mediterranean diet increases macular pigment optical density in humans (0.52 ± 0.14 vs. 0.34 ± 0.18).
“higher adherence was found in the older women in comparison with the younger women (OW 9.23 ± 2.50 vs. YW 7.70 ± 2.08, p < 0.01), with higher MPOD values (OW (0.52 ± 0.14) vs. (YW (0.34 ± 0.18)”
Humanscross-sectional observational studymacular pigmentfemales
Journal of clinical medicine
Blue light exposure
downin humans1
1 study
Blue light exposure
downin humans1
Blue light exposure decreases macular pigment optical density in humans (0.37 ± 0.14 vs. 0.50 ± 0.14, p < 0.01).
“Higher MPOD values are observed with decreasing exposure time to electronic devices with LED lighting screens”
Humanscross-sectional observational studymacular pigmentfemales
Journal of clinical medicine
Grapes
upin humans1
1 study
Grapes
upin humans1
Grapes increase macular pigment optical density in humans (week 0: 0.56 ± 0.04 D.U.; week 16: 0.61 ± 0.04 D.U., p < 0.01).
“A significant time effect (p = 0.007) was observed for MPOD, and this is largely attributed to the improvement in the MPOD for the intervention group”
Human trialfreeze-dried table grape powder46 g day−116 weekn = 34
Food & function
Lutein + zeaxanthin
upin humans1
1 study
Lutein + zeaxanthin
upin humans1
Lutein + zeaxanthin increases macular pigment optical density in humans.
“The supplement group’s MPOD was significantly greater than the control group’s MPOD following the intervention [t(42)=2.44; p=.019], despite the two groups showing comparable MPOD at baseline (p >.05).”
Human trial1 yearn = 44
Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial
Journal of the International Neuropsychological Society : JINS
Upstream
2Age-related macular degeneration
downin humans1
1 study
Age-related macular degeneration
downin humans1
Age-related macular degeneration decreases macular pigment optical density in humans (0.47 ± 0.16 vs 0.35 ± 0.22, p < 0.001).
“The overall mean MPOD in healthy control group and early AMD group were found to be 0.47 ± 0.16 (N = 178; 317 eyes) and 0.35 ± 0.22 (N = 36; 38 eyes) at 1° eccentricity respectively”
Humansat 1° eccentricityn = 214
European journal of ophthalmology
First-degree relative of age-related macular degeneration patient
downin humans1
1 study
First-degree relative of age-related macular degeneration patient
downin humans1
First-degree relative of age-related macular degeneration patient decreases macular pigment optical density in humans (0.43 ± 0.09 vs 0.47 ± 0.12, p = 0.048).
“macular pigment optical density values of Group 1 and Group 2 were 0.43 ± 0.09 and 0.47 ± 0.12 (p = 0.048)”
Humansfirst-degree relatives of age-related macular degeneration patients vs healthy controlseye
Current eye research
Associations
8Primary open-angle glaucoma
downin humans1
1 study
Primary open-angle glaucoma
downin humans1
Macular pigment optical density lowers the risk of primary open-angle glaucoma in humans (P-trend = 0.01).
“Compared with MPOD quartile 1, odds for POAG were lower for women in quartiles 2-4 (P-trend = 0.01).”
Humansfemalesn = 426
Current developments in nutrition
Primary open-angle glaucoma is associated with macular pigment optical density in humans (-25%, 0.40 vs 0.53 ODU, P = 0.01).
“Glaucomatous eyes had 25% lower MPOD compared to nonglaucomatous eyes [mean (SE): 0.40 (0.05) compared with 0.53 (0.01)] optical density units (ODU), respectively (P = 0.01).”
Humansmanifest primary open-angle glaucoma vs nonglaucomatousmaculafemalesn = 426
Current developments in nutrition
Dry age-related macular degeneration
downin humans1
1 study
Dry age-related macular degeneration
downin humans1
Dry age-related macular degeneration is associated with macular pigment optical density in humans (3.69 ± 1.82 vs 4.97 ± 1.27 dB).
“At the baseline, the MPOD of the AMD group was significantly lower than the control group.”
Humansat baseline
European journal of ophthalmology
High-density lipoprotein cholesterol
downin humans1
1 study
High-density lipoprotein cholesterol
downin humans1
High-density lipoprotein cholesterol is associated with macular pigment optical density in humans.
“Serum HDL showed a strong negative association with MPOD and other lipids showed a very weak association.”
Humansn = 214
European journal of ophthalmology
Lutein
upin humans1
1 study
Lutein
upin humans1
Lutein is associated with macular pigment optical density in humans.
“A strong positive association was found between plasma L, Z and L + Z and MPOD.”
Humansn = 214
European journal of ophthalmology
Retinal arteriole caliber
upin humans1
1 study
Retinal arteriole caliber
upin humans1
Macular pigment optical density is associated with retinal arteriole caliber in humans (149.8 ± 2.6 μm vs. 135.8 ± 3.0 μm).
“Most associations were strengthened in women with stable MPOD over 15 years, including between MPOD and arteriole caliber (149.8 ± 2.6 μm vs.135.8 ± 3.0 μm; P = 0.001).”
Humansstable MPOD over 15 yearsretinafemalesn = 106
Investigative ophthalmology & visual science
Retinal venule caliber
upin humans1
1 study
Retinal venule caliber
upin humans1
Macular pigment optical density is associated with retinal venule caliber in humans (213.3 ± 2.1 μm vs. 206.0 ± 2.1 μm).
“MPOD was also associated with wider vessel calibers (tertile 3 vs. 1), but the trend was only statistically significant for venules (144.4 ± 1.4 μm vs. 141.1 ± 1.4 μm [P = 0.12] and 213.3 ± 2.1 μm vs. 206.0 ± 2.1 μm [P = 0.02], respectively.)”
Humansretinafemalesn = 390
Investigative ophthalmology & visual science
Intraindividual variability of attentional control
downin humans1
1 study
Intraindividual variability of attentional control
downin humans1
Macular pigment optical density is associated with intraindividual variability of attentional control in humans.
“younger individuals and individuals with higher MPOD showed less intraindividual variability.”
Humansn = 60
Frontiers in aging neuroscience
P3 amplitude during attentional inhibition
upin humans1
1 study
P3 amplitude during attentional inhibition
upin humans1
Macular pigment optical density is associated with P3 amplitude during attentional inhibition in humans.
“older subjects with higher MPOD levels displayed P3 indices similar to their younger adult counterparts in amplitude.”
Humansn = 60
Frontiers in aging neuroscience