Lysosomal pathway-specific polygenic risk score

1. Lysosomal pathway-specific polygenic risk score raises the risk of Parkinson's disease in humans (OR 1.42, 95% CI 1.36–1.47).

   “LP-PRS was significantly associated with increased PD risk across ancestries, with a pooled odds ratio (OR) estimate of 1.42 (95% CI=[1.36,1.47]) in the European cohorts”

   Humansin European cohorts

   Common variants in the lysosomal pathway contribute to Parkinson's Disease risk

   Research Square·6 Aug 2026Preprint

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