Lymphocyte PMA-stimulated glycolysis

Age decreases lymphocyte PMA-stimulated glycolysis in humans (r=-0.45, p = 0.03).

“Older age (60-88) tended to lower walking distance (r=-0.33), neutrophil oxidant production (r=-0.32), lymphocyte ATP-linked respiration (r=-0.21), and significantly lower PMA-stimulated lymphocyte glycolysis (r=-0.45, p = 0.03).”

HumansHFpEFblood74% femalesn = 23

Blood Immunometabolism Correlates with Exercise Intolerance in Older Adults with Heart Failure

GSA 2025 abstract·31 Dec 2025