Lower Extremity Functional Index

1. Lower Extremity Functional Index is associated with depression in humans (OR 0.51, 95% CI 0.35–0.74 per 1-SD increase).

   “corresponding LEFI estimates were 0.65 (95% CI: 0.47-0.90) and 0.51 (95% CI: 0.35-0.74).”

   HumansStable COPD; adjusted association per 1-standard deviation increase in LEFI; Patient Health Questionnaire-9 score ≥1058.3% malesn = 120

   Relationship between upper and lower limb function, cognitive impairment, and depression in patients with chronic obstructive pulmonary disease: A cross-sectional study

   Medicine·17 Oct 2025

More on Depression

1. Lower Extremity Functional Index is associated with cognitive impairment in humans (OR 0.65, 95% CI 0.47–0.90 per 1-SD increase).

   “corresponding LEFI estimates were 0.65 (95% CI: 0.47-0.90) and 0.51 (95% CI: 0.35-0.74).”

   HumansStable COPD; adjusted association per 1-standard deviation increase in LEFI58.3% malesn = 120

   Relationship between upper and lower limb function, cognitive impairment, and depression in patients with chronic obstructive pulmonary disease: A cross-sectional study

   Medicine·17 Oct 2025

More on Cognitive impairment