Life's Simple 7
Biomarker3 papers4 findings
- Humans3
Upstream
1Neutrophil-to-lymphocyte ratio
mediatesin humans1
1 study
Neutrophil-to-lymphocyte ratio
mediatesin humans1
Neutrophil-to-lymphocyte ratio mediates Life's Simple 7 in humans (8.8% mediated, P < 0.001).
HumansRLS and LS7 associationfemalesn = 1,673
Reproductive lifespan and cardiovascular health in postmenopausal women: a non-linear, behavior-driven association with cross-population validation · Frontiers in medicine · 31 Aug 2026
Associations
3Mortality
downin humans1
1 study
Mortality
downin humans1
Life's Simple 7 lowers the risk of mortality in humans.
Humansn = 1,466
Life's Simple 7, depressive symptoms, cognitive performance, and their associations with all-cause mortality among middle-aged urban adults · GeroScience · 24 Sep 2026
Premature mortality
downin humans1HR 0.852
1 study
Premature mortality
downin humans1HR 0.852
Life's Simple 7 lowers the risk of premature mortality in humans (HR 0.852).
HumansCKM overall populationmedian follow-up of 7.75 yearsn = 8,532
LS7, LE8, and LC9 for Premature Mortality in CKM Syndrome: Robust Stratification in Early Stages but Attenuated Discriminative Ability in Stage 4 · Research Square · 14 Sep 2026 · Preprint
Reproductive lifespan
upin humans1
1 study
Reproductive lifespan
upin humans1
Reproductive lifespan is associated with Life's Simple 7 in humans (β = 0.038, P = 0.048).
HumansRLS ≤ 37 yearsfemalesn = 1,673
Reproductive lifespan and cardiovascular health in postmenopausal women: a non-linear, behavior-driven association with cross-population validation · Frontiers in medicine · 31 Aug 2026
Latest
8Carotid thickness partly mediates cardiovascular health benefits
Carotid intima-media thickness mediated 3.64% of the link between cardiovascular health metrics and disease events in 358,650 adults.Carotid intima-media thickness mediated 3.64% of the link between cardiovascular health metrics and disease events in 358,650 adults.