What does the research say about left ventricular geometry?

Left ventricular geometry

There are 5 papers on left ventricular geometry in aging research: 1 trial and 5 observational studies in people. The newest story, Nov 8, 2026: “Semaglutide improved heart filling in obesity-related heart failure”.

Biomarker

5 papers study it12 more mention it2 findings

5 new papers in 30 daysSee all 18 papers on left ventricular geometry

“gGeom, reflecting greater myocardial mass, wall thickness, and ventricular volumes, showed the strongest association with hippocampal volume [β = 0.082 (0.048-0.117) in females; β = 0.039 (0.006-0.071) in males]”

Left ventricular geometry, brain architecture, and cognition: an observational studyEuropean heart journal2025doi:10.1093/eurheartj/ehaf722

Human trial1
Humans5

Associations

Cognitive function

upin humans1

1 study

Left ventricular geometry is associated with cognitive function in humans.
“was the only CV phenotype associated with better cognition, including higher fluid intelligence and faster reaction time.”
Humansn = 15,519
Left ventricular geometry, brain architecture, and cognition: an observational study
European heart journalOct 9, 2025

Hippocampal volume

upin humans1

1 study

Left ventricular geometry is associated with hippocampal volume in humans (β = 0.082 (0.048-0.117)).
“gGeom, reflecting greater myocardial mass, wall thickness, and ventricular volumes, showed the strongest association with hippocampal volume [β = 0.082 (0.048-0.117) in females; β = 0.039 (0.006-0.071) in males]”
Humanshippocampusfemalesn = 15,519
Left ventricular geometry, brain architecture, and cognition: an observational study
European heart journalOct 9, 2025

Latest

9 papers in 12 months

Nature MedicineNov 8

Semaglutide improved heart filling in obesity-related heart failure

Semaglutide improved how much the heart’s upper left chamber stretched by 5.7 percentage points versus placebo over 52 weeks in a 49-person trial substudy.Semaglutide improved how much the heart’s upper left chamber stretched by 5.7 percentage points versus placebo over 52 weeks in a 49-person trial substudy.

Randomized trial · 49 peopleSemaglutide