Large clonal hematopoiesis of indeterminate potential

1. Large clonal hematopoiesis of indeterminate potential increases ELANE in humans.

   “revealed hypomethylation and increased transcription of genes implicated in neutrophil extracellular trap formation, including ELANE, PTRN3, AZU1, and CTSG”

   Humanscompared to no CHIPwhole blood

   Multi-omic Characterization of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) Trials Biorepository

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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1. Large clonal hematopoiesis of indeterminate potential activates immune response in humans.

   “we found 58 pathways to be both hypomethylated and transcriptionally upregulated in large CHIP, including azurophil granule-related pathways implicated in neutrophil degranulation”

   Humanscompared to no CHIPwhole blood

   Multi-omic Characterization of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) Trials Biorepository

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Immune response