L1 subfamily RNA expression variance

L1 subfamily RNA expression variance is associated with age at last birth in humans (Pearson r = -0.44, p = 0.02).

“strong association of higher intra-individual variance in L1 RNA expression across the 127 L1 subfamilies with a younger ALB (Pearson r = -0.44, p = 0.02)”

Humanssurvived at least five years after blood drawlymphoblastoid cell linesfemalesn = 27

Association of LINE-1 RNA expressions in cell lines with longevity and reproductive lifespan

medRxiv : the preprint server for health sciences·19 Dec 2025Preprint

L1 subfamily RNA expression variance raises the risk of mortality in humans (HR 3.84, 95% CI 1.49-10.72, P = 0.0068).

“for top half vs. bottom half variance across the L1 subfamilies, HR 3.84, 95% CI 1.49-10.72, P = 0.0068”

Humanslymphoblastoid cell linesfemales

Association of LINE-1 RNA expressions in cell lines with longevity and reproductive lifespan

medRxiv : the preprint server for health sciences·19 Dec 2025Preprint