IR tyrosine phosphorylation

1. Caloric restriction increases IR tyrosine phosphorylation in rats.

   “aging was accompanied by a significant decrease in IR tyrosine phosphorylation after insulin stimulation in live and skeletal muscle, which was associated with a significant increase in the activity of protein tyrosine phosphatase-1B. However, these age-related alterations were attenuated by long-term calorie restriction.”

   Animals60% of the ad libitum amountliver and skeletal muscle25 momales

   Caloric restriction modulates insulin receptor signaling in liver and skeletal muscle of rat

   Nutrition (Burbank, Los Angeles County, Calif.)·1 Mar 2005

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