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Intrinsic capacity deficit proxy score

Biomarker

1 paper2 findings

  • Humans1

Effects

1

Life expectancy

downin humans1

1 study

  1. Intrinsic capacity deficit proxy score decreases life expectancy in humans (1.09 years lost in life expectancy; 95% CI, 0.68-1.51).

    “Among individuals with CKD, a higher IC deficit proxy score (3+) was linked to reduced life expectancy at age 45 years (1.09 years lost in life expectancy; 95% CI, 0.68-1.51).”

    Humansamong individuals with CKD

    Associations of intrinsic capacity deficit proxy score and genetic susceptibility with incident chronic kidney disease and life expectancy

    The journals of gerontology. Series A, Biological sciences and medical sciences5 Oct 2025

Associations

1

Chronic kidney disease

upin humans1HR 1.16

1 study

  1. Intrinsic capacity deficit proxy score raises the risk of chronic kidney disease in humans (HR = 1.16, 95% CI, 1.14, 1.18).

    “A one-point increment in the IC deficit proxy score was associated with a higher risk of developing CKD (HR = 1.16, 95% CI, 1.14, 1.18; P-trend < .0001)”

    Humans

    Associations of intrinsic capacity deficit proxy score and genetic susceptibility with incident chronic kidney disease and life expectancy

    The journals of gerontology. Series A, Biological sciences and medical sciences5 Oct 2025

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