Initial IFN-γ response

Premature thymic involution is associated with initial IFN-γ response in mice.

“Foxn1lacz peripheral T cells had reduced IL-2 secretion and strong initial IFN-γ responses, resembling aged wild-type peripheral T cell responses.”

AnimalsFoxn1lacz mutant mice, following T cell receptor stimulationperipheral T cell

Premature thymic involution in young Foxn1lacz mutant mice causes peripheral T cell phenotypes similar to aging-induced immunosenescence

Journal of immunology (Baltimore, Md. : 1950)·18 Aug 2025