Inflammatory microglial dominance probability

Chronological age is associated with inflammatory microglial dominance probability in humans (26% at age 35 to 92% by age 65).

“with inflammatory dominance probability rising from 26% at age 35 to 92% by age 65, replicated in an independent cohort.”

Humansmicroglian = 226

Microglia as transcriptional pacemakers of neuronal aging heterogeneity across individuals

bioRxiv (Cold Spring Harbor Laboratory)·8 Apr 2026Preprint